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Chiefly correspondence relating to medicine, public health and details on laboratory techniques at the turn of the century.Important medical correspondents include Richard H. Derby, Alva H. Doty, Henry Hun, Abraham Jacobi, Charles McBurney, W.P. Northhrup, Edward L. Trudeau, Ira Van Gieson, William Henry Welch, and in Germany, Julius Arnold, Robert Koch and Rudolf Virchow. Prudden's interest in the Indians of Southwestern United States is documented in his correspondence with anthropologists and writers on the West such as George Grant MacCurdy, George H. Pepper, C. Hart Merriam, F. W. Hodge, F.S. Dellenbaugh, and Charles F. Lummis.Also in the papers are photographs of Prudden, biographical notes, memorabilia and writings (1875-1910).Among these are his dissertation, typescripts of published and unpublished essays, pamphlets and clippings, all largely on public health.Diaries of two scientific expeditions, one with G.H. Isham to Eastport, Maine in 1872 and the other with O.C. Marsh to the West in 1873 are the earliest items in the papers.