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Piozzi writes that she has arrived in London, but suffered from bad nerves along the road. She discusses political and social news concerning the nobility and complains that she left spring behind "in North Wales." People mentioned: Selina Thackeray, Lord Dundonald, Lord Cochrane, Mr. Wandle, Sir Lucas Pepys, Lady Caroline Paget, Lady William Russell and Lady Jersey.

Piozzi passes on regards from her nephew Salusbury, who will attend Christ Church, Oxford, and his friend Mr. Shephard, who attended Eton. Both young men have helped Mrs. Piozzi in her grief. People mentioned: Salusbury, Mr. Shephard, Mr. Shephard's father and Jackson's [?].

Piozzi plans to travel to London to visit her daughters. Piozzi still grieves for her husband, but has received some comfort from Salusbury settling her "future concerns". She plans to stay at Jackson's Hotel in London because she "cannot bear either Society or Solitude" and she quotes a newspaper paragraph about her husband's burial. People mentioned: Piozzi's daughters, Salusbury, William Shephard, Mrs. Thackeray, Selina Thackeray and Gabriel Piozzi.

Mr. Piozzi has improved after Dr. Thackeray's visit and has been taking opiates to combat symptoms. Mrs. Piozzi fears he "is now doomed & destined to take some Narcotic Medicine for the remainder of this Year 1809." However, the opiates allow Mr. Piozzi to consume less brandy. Surprisingly, even Mr. Piozzi agrees that he is feeling better. Life is dull, and Mrs. Piozzi wonders if it is safe for Mr. Piozzi to drink beer. People mentioned: Mr. Piozzi, Mrs. Clarke, Mrs. Mostyn, Salusbury and Mr. Moore.

Piozzi begs Dr. Thackeray to come. Mr. Piozzi is vomiting and feverish. Mr. Moore continues the letter on the verso in [50b]. People mentioned: Mr. Piozzi and Mr. Moore.

Mr. Piozzi is ill again and woke one night "in something like a delirious Fury." Mr. Piozzi raves, but Mrs. Piozzi hopes that rest will help him, and says that as long as she keeps her "own Wits," she would not change "with the King or Duke of York." She also comments on current affairs and writes that some of the tales of monsters are indeed true. People mentioned: Mr. Piozzi, Mr. Moore, the King, the Duke of York, Mr. Robson of Chirk, Mrs. Yorke, the Emperor of China, "some Fasting Woman" and Cecilia Mostyn.

Piozzi writes that sleep cured her husband's deliriums, but his gout is still painful. People mentioned: Mr. Piozzi.

On the verso of [50a], Mr. Moore writes that he left Mr. Piozzi "considerably better," but is still desirous of Dr. Thackeray's advice. People mentioned: Mr. Piozzi.

Mr. Piozzi's health worsens. Mrs. Piozzi discusses the threat of Irish rebellion and the "perverse" behavior of the "old King." She enquires after Dr. Thackeray's sister Kilfenora. Mr. Moore says that some of Mr. Piozzi's symptoms are "merely nervous" and don't pose any danger, but Mrs. Piozzi's doubts him, saying Mr. Moore "says some same of the State." People mentioned: Mr. Moore, Mr. Piozzi, the King, Kilfenora and Selina.

Piozzi discusses mutual friends and quotes Dr. Johnson. People mentioned: Sir Lucas Pepys, Mrs. Mostyn, Mrs. Mostyn's three sons, Dr. Myddleton, the Dean of St. Asaph, Mr. Moore, Mrs. Clarke, Dr. Johnson, Salusbury, Mr. Thrale, "The Ladies" (Mr. Thrale's daughters), farmer Jones and farmer Jones's wife.