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The principal figures in these papers are Phillips Foster Greene, a physician and missionary, and his wife, Ruth Altman Greene, a teacher and writer who accompanied her husband during his service of nearly twenty years at the Yale-in-China Medical School in Changsha (1921-1943) and seven years in Rangoon (1951-1958). The papers consist largely of correspondence with family in the United States and with Yale-in-China staff members. The letters are important sources of information on social conditions in China and political events, as well as a record of the Greenes' day-to-day activities. Also in the papers are financial records, newspaper clippings, copies of their articles on life at Changsha, and photographs.

The records document the activities of the Yale-China Association in mainland China (1901-1951), Hong Kong (1951-present), and the United States (1901-present). They consist of administrative and policy files produced by the home office in New Haven, correspondence and memoranda written by staff members while serving in China, and administrative files and correspondence produced by the New Asia office in Hong Kong.