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The papers consist of correspondence, reading notes, writings and research materials relating primarily to Hans C. Syz's career as secretary and president of the Lifwynn Foundation. The papers provide information on the formation and development of the Lifwynn Foundation, as well as research and writing by staff members and students. Syz's work as a psychiatrist in New York and Baltimore hospitals is also documented, as are his activities as a collector of 18th-century Western European porcelain.

The papers contain correspondence, memoranda, manuscripts and other papers on the professional career and personal life of psychiatrist and psychoanalyst Trigant Burrow. The papers document Burrow's group laboratory research, the activities of The Lifwynn Foundation, the research of important colleagues like Hans C. Syz and Charles Baker Thompson, and such subjects as doctor-patient and interpersonal relations. The papers include extensive family and personal correspondence, a complete set of Burrow's published writings, drafts of manuscripts, and copies of unpublished and unfinished writings. Major correspondents include Sherwood Anderson, Sigmund Freud, Carl G. Jung, Alfred Korzybski, D. H. Lawrence, Adolf Meyer, Sir Herbert Read, Clarence Shields, and Leo Stein.