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The records consist of administrative and subject files, annual reports, financial records, publications, and correspondence documenting the activities of the Institute of Human Relations at Yale. Topics include fund-raising, special studies, associations and conferences, fellowships, and research.

The papers consist of correspondence, reading notes, writings and research materials relating primarily to Hans C. Syz's career as secretary and president of the Lifwynn Foundation. The papers provide information on the formation and development of the Lifwynn Foundation, as well as research and writing by staff members and students. Syz's work as a psychiatrist in New York and Baltimore hospitals is also documented, as are his activities as a collector of 18th-century Western European porcelain.

The papers contain correspondence, writings, subject files and personal papers documenting the personal life and writing career of Elizabeth Shepley Sergeant and such subjects as the Taos writers colony, the Indian rights movement, popular psychology, and life in Paris during World War I. Major correspondents include Randolph Bourne, John Collier, Alyse Gregory, Sidney Howard, Haniel Long, Amy Lowell, Mabel Dodge Luhan, and Thornton Wilder.

The collection consists of writings, sheet music, scrapbooks, photographs, and other papers, stemming from R. A. Adams's activities as an evangelistic minister of the African Methodist Episcopal Church and as a writer, lecturer, and publisher of pamphlets on topics relating to race, religion, contraception, interpersonal relations, and socioeconomics. The collection documents aspects of African American religion and culture, especially in the South, in the early 20th century, and in particular the evangelistic, educational, and literary activities of one African American Methodist minister.

The papers contain correspondence, memoranda, manuscripts and other papers on the professional career and personal life of psychiatrist and psychoanalyst Trigant Burrow. The papers document Burrow's group laboratory research, the activities of The Lifwynn Foundation, the research of important colleagues like Hans C. Syz and Charles Baker Thompson, and such subjects as doctor-patient and interpersonal relations. The papers include extensive family and personal correspondence, a complete set of Burrow's published writings, drafts of manuscripts, and copies of unpublished and unfinished writings. Major correspondents include Sherwood Anderson, Sigmund Freud, Carl G. Jung, Alfred Korzybski, D. H. Lawrence, Adolf Meyer, Sir Herbert Read, Clarence Shields, and Leo Stein.