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The records consist of correspondence and administrative files documenting the operations and activities of the School of Epidemiology and Public Health (a department within the Yale School of Medicine). Materials include an administrative subject-correspondence file, curriculum and student records, surveys, hospital administration materials, financial papers and grants, student and course files, and information on the Edwin Weinerman Memorial Fund.

The Medical and Scientific Collection contains various medical journals and personal documents regarding illness. Documents include various notebooks kept during medical school as well as during practice by several Waterbury doctors. Also included in the collection are city announcements on recent outbreaks of diseases such as Typhoid fever and on the effectiveness of the smallpox inoculation. Also represented are various personal accounts regarding illnesses such as whooping cough.

Park City Hospital was founded in 1924, meant to serve the downtown Bridgeport community and provide quicker access for emergencies for those who could not speedily access the northern Bridgeport or St. Vincent's hospitals. This smaller hospital served the community until 1993, and helped to provide high quality care to the immediate area. These records reflect this community impact through clippings, publicity documentation, and newsletters, along with annual reports among other documents.

First established as a program within the Labor Management Institute in 1946, the Labor Education evolved into a separate center in 1961. Its purpose is to fulfill the educational, consultation, and research needs of the state's unions.

The Waterbury Hospital Papers contain various documents regarding the history of Waterbury Hospital from the late 1800s through the early 2000s. Documents include photographs, records books, and hospital magazines. Photographs depict the children's ward, radiology center, operating room, and other medical procedures. Additionally, the collection contains information about the Waterbury Nursing School which was associated with the hospital. Items include a scrapbook kept by a nursing student in 1935 and an oral history interview with Ginger Golymbieski, a former student who then worked at the hospital. The interview details her schooling and practice as a nurse.