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The Waterbury Hospital Papers contain various documents regarding the history of Waterbury Hospital from the late 1800s through the early 2000s. Documents include photographs, records books, and hospital magazines. Photographs depict the children's ward, radiology center, operating room, and other medical procedures. Additionally, the collection contains information about the Waterbury Nursing School which was associated with the hospital. Items include a scrapbook kept by a nursing student in 1935 and an oral history interview with Ginger Golymbieski, a former student who then worked at the hospital. The interview details her schooling and practice as a nurse.

The Medical and Scientific Collection contains various medical journals and personal documents regarding illness. Documents include various notebooks kept during medical school as well as during practice by several Waterbury doctors. Also included in the collection are city announcements on recent outbreaks of diseases such as Typhoid fever and on the effectiveness of the smallpox inoculation. Also represented are various personal accounts regarding illnesses such as whooping cough.