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The papers consist of correspondence, reading notes, writings and research materials relating primarily to Hans C. Syz's career as secretary and president of the Lifwynn Foundation. The papers provide information on the formation and development of the Lifwynn Foundation, as well as research and writing by staff members and students. Syz's work as a psychiatrist in New York and Baltimore hospitals is also documented, as are his activities as a collector of 18th-century Western European porcelain.