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The papers contain correspondence, reports, minutes of meetings, research notes, writings, photographs, diaries, and other materials documenting the professional career and personal life of Robert Mearns Yerkes. The papers document the broad range of psychological activities undertaken by Yerkes in the first half of the twentieth century. The papers contain correspondence and other materials on chimpanzee and gorilla behavior, intelligence testing in World War I, eugenics and immigration restriction, sex research under the auspices of the National Research Council's Committee for Research in Problems of Sex, research into the behavior of lower animals, and efforts to establish psychology as an experimental science. The papers include notes on chimpanzee and gorilla research, a complete set of his published writings, professional and personal photographs, and extensive files providing information on family life.

The papers contain correspondence, memoranda, manuscripts and other papers on the professional career and personal life of psychiatrist and psychoanalyst Trigant Burrow. The papers document Burrow's group laboratory research, the activities of The Lifwynn Foundation, the research of important colleagues like Hans C. Syz and Charles Baker Thompson, and such subjects as doctor-patient and interpersonal relations. The papers include extensive family and personal correspondence, a complete set of Burrow's published writings, drafts of manuscripts, and copies of unpublished and unfinished writings. Major correspondents include Sherwood Anderson, Sigmund Freud, Carl G. Jung, Alfred Korzybski, D. H. Lawrence, Adolf Meyer, Sir Herbert Read, Clarence Shields, and Leo Stein.