The collection consists of material gathered by Lindsay Fleming in the course of his research on the life and work of Samuel Lysons, and includes correspondence with scholars and Lyson family descendants; transcripts of portions of Lysons's diary and his letters to Hester Thrale Piozzi; the typsecript of Fleming's "Memoirs and Select Letters of Samuel Lysons"; photographs; and letters to and from Daniel and Samuel Lysons. The correspondence of Daniel Lysons mainly concerns his topographical studies; the correspondence of Samuel Lysons documents his antiquarian interests and his work as Keeper of the Records. Correspondents include William Coxe, Sir Thomas Lawrence, Thomas Penrose, and Wilfred Merton.