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The General Files consist principally of correspondence between Syz and his colleagues in psychiatry and medicine. Other correspondents include professional organizations, literati, students and associates of the Lifwynn Foundation, and friends of the Syz family. The files are arranged alphabetically, and a guide to the correspondence prepared by Syz in folder one provides some topical indexing. The series contains little correspondence of a personal nature. Most folders include both incoming and outgoing correspondence. Other material in the files include memoranda of meetings, clippings, reprints, manuscripts and newsletters. The bulk of correspondence falls between 1926 and 1981.